恶性黑色素瘤、肾癌、实体瘤生物免疫治疗

　郭军，男，主任医师，教授，1966年11月出生，现任北京肿瘤医院肾癌黑色素瘤内科主任，医学博士，教授，主任医师。中国临床肿瘤协会(CSCO)黑色素瘤专家委员会主任委员，中国抗癌协会肾癌专业委员会常务委员，中国晚期肾癌治疗专家委员会成员。国际黑色素瘤专家委员会GMTF(Golbal Melanoma TaskForce)委员，国际黑色素瘤研究联盟(Society for Melanoma Research)常务委员，国际黑色素瘤监督委员会候补委员，黑色素瘤国际基金会(MIF)海外咨询顾问。国家教育部 “新世纪优秀人才支持计划”入选者，北京市“十百千”卫生优秀人才基金获得者。«Melanoma Research»，«Journalof Cancer Research and Clinical Oncology»，«中国肿瘤临床»等杂志特约审稿专家，国家自然科学基金评审专家。在国际著名医学杂志上(Blood, Gene Ther, Int J Cancer等)发表论著10余篇。作为项目负责人，承担国家自然科学基金面上项目等多项基金课题。 Publications 　1. Guo J, Zhu J, Sheng X, Wang X, Qu L, Han Y,Liu Y, Zhang H, Huo L, Zhang S, Lin B, Yang Z. Intratumoral injection of dendritic cells in combination with local hyperthermia induces systemic antitumor effect in patients with advanced melanoma. Int J Cancer. 2007 June 120(11):2418-25 　　2. Chen T, Guo J, Yang M, Han C, Zhang M, Chen W, Liu Q, Wang J, Cao X. Cyclosporin A impairs dendritic cell migration by regulating chemokine receptor expression and inhibiting cyclooxygenase-2 expression. Blood. 2004 Jan 15;103(2):413-21. 　3. Zhang M, Tang H, Guo Z, An H, Zhu X, Song W, Guo J, Huang X, Chen T, Wang J, Cao X. Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells.Nat Immunol. 2004 Nov;5(11):1124-33 　4. Guo J, Zhang M, Wang B, Yuan Z, Guo Z, Chen T, Yu Y, Qin Z, Cao X. Fractalkine transgene induces T cell-dependent antitumor immunity through chemoattraction and activation of dendritic cells. Int J Cancer 2003, Jan; 130(2):213-220 　5. Guo J, Chen T, Wang B, Zhang M, An H, Guo Z, Yu Y, Qin Z, Cao X. Chemoattraction, adhesion and activation of natural killer cells are involved in the antitumor immune response induced by fractalkine/CX3CL1. Immu Lett 2003 Oct 9;89(1):1-7. 　6. Guo Z, Zhang M, An H, Chen W, Liu S, Guo J, Yu Y, Cao X. Fas ligation induces IL-1beta-dependent maturation and IL-1beta-independent survival of dendritic cells: different roles of ERK and NF-kappaB signaling pathways. Blood. 2003 Dec 15;102(13):4441-7. 　7. Chen T, Han Y, Yang M, Zhang W, Li N, Wan T, Guo J, Cao X. Rab39, a novel Golgi-associated Rab GTPase from human dendritic cells involved in cellular endocytosis. Biochem Biophys Res Commun. 2003 Apr 18;303(4):1114-20. 　8. Guo J, Wang B, Zhang M, Chen T, Yu Y, Regulier E, Homann HE, Qin Z, Ju DW, Cao X. Macrophage-derived chemokine gene transfer results in tumor regression in murine lung carcinoma model through efficient induction of antitumor immunity. Gene Ther 2002 9(12):793-803